Phthalic acid and derivatives
Medchemexpress LLC Cyclic GMP sodium | 40732-48-7 | 99.9% | 367.19 | 10 MG
Cyclic GMP sodium | 40732-48-7 | 99.9% | 367.19 | 10 MG
Apexbio Technology LLC Cyclic somatostatin 38916-34-6 5mg
Cyclic somatostatin is a cyclic peptide neurohormone that targets somatostatin receptors It functions as an inhibitor of growth hormone secretion through interaction with these receptors thereby regulating neuroendocrine and cardiovascular pathways Cyclic somatostatin exerts its biological activity primarily by inhibiting isoproterenol-induced responses in ventricular myocytes and modulating myocardial contraction It is stored and co-released with acetylcholine from cardiac parasympathetic nerves Based on these pharmacological properties cyclic somatostatin holds research potential in studies of acute gastro-duodenal ulcer bleeding and in the investigation of receptor-mediated signaling pathways in cardiovascular and neuroendocrine systems Its defined molecular structure also enables its use as a reference standard in analytical assays
Medchemexpress LLC Cyclic GMP (TBAOH) | 99.1% | 604.68 | 1 ML
Cyclic GMP (cGMP) TBAOH is an important second messenger and a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Its effects occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.
- Important second messenger
- Major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs)
- Affects cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs
- Can inhibit both platelet adhesion and aggregation
- A conjugate can enhance antiviral immune responses
Medchemexpress LLC Terephthalic acid-13C2 | 121191-53-5 | 99.6% | 168.12 | 25 MG
Terephthalic acid-13C2 is the 13C-labeled version of Terephthalic acid. Terephthalic acid is an isomer and a precursor of polyester PET, which is used in clothing and plastics. It can also be utilized to create skin tumor models.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis via NMR, GC-MS, or LC-MS.
- Stable heavy isotopes, such as carbon-13 (13C), are incorporated into drug molecules primarily as tracers for quantification during drug development.
Apexbio Technology LLC Cyclic Pifithrin-α hydrobromide 511296-88-1 10mg
Cyclic Pifithrin- hydrobromide (CAS 511296-88-1) is a synthetic small molecule that functions as an inhibitor of the tumor suppressor protein p53 By blocking p53-dependent transcriptional activation of response genes it interferes with p53-mediated cellular processes such as apoptosis and cell cycle arrest In vitro Cyclic Pifithrin- hydrobromide inhibits p53-dependent apoptosis and DNA damage-induced growth arrest in various cell models without notable effects on p53-deficient cells In vivo it protects mice from the toxic side effects of genotoxic cancer therapies likely through suppression of p53-dependent pathways This compound is utilized in research investigating p53 biology cellular stress responses and modulation of chemotherapeutic toxicity
Medchemexpress LLC Cyclic GMP (Standard) | 7665-99-8 | 99.5% | 345.21 | 25 MG
Cyclic GMP (Standard) | 7665-99-8 | 99.5% | 345.21 | 25 MG
TARGETMOL CHEMICALS INC AG-636 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. AG-636 is a potent, reversible, and selective DHODH inhibitor with an IC50 of 17 nM and is orally active. It demonstrates strong anticancer effects. Purity 99.19%
Medchemexpress LLC Guanosine, cyclic 3',5'-(hydrogen phosphate) (TBAOH) | 99.1% | 604.68 | 10 MG
Cyclic GMP (cGMP) TBAOH is an important second messenger and a major intracellular mediator of extracellular signals like nitric oxide (NO) and natriuretic peptides (NPs). Its effects are mediated through cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.
- Important second messenger
- Intracellular mediator of extracellular signals (nitric oxide and natriuretic peptides)
- Inhibits both platelet adhesion and aggregation
- Can activate cGMP-mediated protein kinases
- Can activate cGMP-stimulated phosphodiesterases when acting synergistically with Isoprenaline, reversing cAMP-mediated enhancement or inhibiting cAMP-induced inward calcium current (ICa)
Medchemexpress LLC Cyclic GMP sodium | 40732-48-7 | 99.9% | 367.19 | 25 MG
Cyclic GMP (cGMP) sodium is an important second messenger and a major intracellular mediator of extracellular signals like nitric oxide (NO) and natriuretic peptides (NPs). Its effects are mediated through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and phosphodiesterases (PDEs). It can inhibit both platelet adhesion and aggregation, and its conjugate, cGAMP, can enhance antiviral immune responses.
- Important second messenger.
- Major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs).
- Mediates effects through cGMP-dependent protein kinases, cGMP-gated cation channels, and PDEs.
- Inhibits platelet adhesion and aggregation.
- Can enhance antiviral immune responses through its conjugate.
- Activates cGMP-stimulated phosphodiesterases synergistically with Isoprenaline.
Medchemexpress LLC 8-CPT-Cyclic AMP sodium | 93882-12-3 | 99.7% | 493.79 | 100 MG
8-CPT-Cyclic AMP sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). It is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM, and it inhibits PDE III and PDE IV with IC50Epac, functioning as a potent Epac activator.
- Delays TNF-α/CHX-induced and α-Fas-induced apoptosis in neutrophils.
- More effective against apoptosis induced by TNF-α/CHX than by α-Fas.
eMolecules 28179-47-7 | MONOMETHYL-5-AMINO-ISOPHTHALATE | AstaTech | MFCD00224870 | 195.174 | C9H9NO4 | 95.000 | COC(=O)c1cc(N)cc(c1)C(O)=O | 5g | 233616389
MONOMETHYL-5-AMINO-ISOPHTHALATE | AstaTech | 28179-47-7 | MFCD00224870 | 195.174 | C9H9NO4 | 95.000 | COC(=O)c1cc(N)cc(c1)C(O)=O | 5g | 233616389
Medchemexpress LLC Fosbretabulin disodium | 168555-66-6 | 99.9% | 440.29 | 1 MG
Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. It is a Combretastatin A4 proagent that selectively targets endothelial cells, induces regression of nascent tumor neovessels, reduces tumor blood flow, and causes central tumor necrosis.
- Tubulin destabilizing agent
- Selectively targets endothelial cells
- Induces regression of nascent tumor neovessels
- Reduces tumor blood flow
- Causes central tumor necrosis
- For research use only
Apexbio Technology LLC Disodium (R)-2-Hydroxyglutarate 103404-90-6 10mM (in 1mL H2O)
Disodium (R)-2-Hydroxyglutarate (CAS 103404-90-6) is an enantiomer of 2-hydroxyglutarate that functions as an inhibitor of ATP synthase a rotary enzyme complex critical for ATP production via oxidative phosphorylation Studies have shown that (R)-2-hydroxyglutarate accumulates in human cancers harboring IDH1 or IDH2 mutations where it suppresses ATP synthase activity leading to tumor cell growth arrest and cell death particularly under glucose-limited conditions In IDH-mutant glioma cells elevated (R)-2-hydroxyglutarate levels reduce oxygen consumption linked to ATP synthase This molecule is used to investigate metabolic vulnerabilities in malignancies with altered 2-hydroxyglutarate metabolism and the role of ATP synthase in cancer cell survival